Jevtana cabazitaxel 60 mg for sale

 Jevtana cabazitaxel 60 mg for sale

Dosage Forms & Strengths

injectable solution

• 60mg/1.5mL

Prostate Cancer

Indicated in combination with prednisone for hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing regimen

25 mg/m² IV q3Weeks; infuse IV over 1 hr  

Give with prednisone 10 mg PO qDay (ie, administer prednisone every day throughout course of treatment with cabazitaxel)

Dose modification

• Reduce dose to 20 mg/m² with following reactions
• Febrile neutropenia or prolonged (>1 week) neutropenia grade 3 or greater: Delay until neutrophil count is >1500/mm³, and then reinitiate at reduced dose; consider G-CSF for secondary prophylaxis
• Persistent diarrhea or diarrhea grade 3 or greater: Delay until improvement, and then reinitiate at reduced dose of 20 mg/m²
• Grade 2 peripheral neuropathy: Delay treatment until improvement or resolution; then reduce dose to 20 mg/m²
• Grade 3 peripheral neuropathy: Discontinue therapy
• Discontinue if reactions persist despite reduced dose

Hepatic Impairment

Mild hepatic impairment (total bilirubin > 1 to ≤ 1.5 x upper limit of normal (ULN) or AST >1.5 x ULN): Reduce dose to 20 mg/m²

Moderate hepatic impairment (total bilirubin > 1.5 to ≤ 3 x ULN and AST = any): 15 mg/m²

Severe hepatic impairment (total bilirubine >3 x ULN): Contraindicated

Administration

Vial contents require 2 dilutions prior to administration

Use entire contents of accompanying diluent to achieve a concentration of 10 mg/mL

Antiemetic prophylaxis recommended as needed

Premedication regimen

• Initiate premedication 30 minutes before each dose Antihistamine (eg, diphenhydramine 25 mg IV) Corticosteroid (dexamethasone 8 mg IV or equivalent) H2-antagonist (eg, ranitidine 50 mg IV)

Other Information

Use cytotoxic precautions for handling, administration, and disposal

Next: Interactions

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